Is it possible to maintain your weight during the holidays and still enjoy food?
The short answer is yes, you can maintain your current fitness level. Even if you notice mild weight gain within a couple of days after a festive meal, you can prevent ending up with extra weight at the end of the holiday season.
The festive period is the time to eat our favorite foods with our favorite people. There is absolutely nothing wrong with that! Learning how to prevent excessive weight gain on holidays without giving up on festive meals is an important part of your fitness journey!
Here are five tips to stay as fit as possible during the holidays and enjoy your meals:
1. Invite your friends and cook instead of eating outside often
Prepare your holiday meals and snacks from scratch for better control over how much you eat. You can use the NHS calorie checker to insert your ingredients and estimate the recipe’s energy content. You do not have to make “low calorie” meals your guests may not enjoy. You can have a small portion size and have more vegetables to feel full for longer! This is probably the most effective way to stick to your usual calorie intake during the holidays and avoid unnecessary weight gain!
2. Stick to your regular healthy eating habits as many days as possible
The festive seasons lasts for six weeks, but you will not have to eat festive food with friends all the time. You can stick to your regular healthy meals for as many days as you can!
Please avoiding undereating/not eating the days between holiday meals. You may end up eating even more when you join a festive meal because of extreme calorie restriction. Also, this eating behavior does not help you to build a healthy relationship with food!
It is more than enough to eat your 5 a day , stick to your usual balanced meals and avoid stocking up holiday treats!
Greek Christmas honey cookies (melomakarona). A devine creation with 160-220 kcal per piece. Stocking them might not be the best idea, but you need to try them! Photo by mariatikka_nutr .
3. Stick to your main meal at restaurants and choose your drinks wisely
If you plan to eat outside often during the holidays, you can totally order the holiday meal you want to try. The trick to stick to this meal as much as possible. Appetizers and desserts you can have throughout the year can wait for next month. You could also share a dessert or appetizer with your friends!
Many drinks contain the calories of a small meal. Safe options include black coffee or coffee with semi- skimmed milk, sugar-free soda and up to two small glasses of dry wine, if you drink alcohol. If you avoid cocktails, sugary drinks and mixed fruit juice, you would be surprised by the weight gain you can avoid during the holidays!
4. Continue working out to prevent holiday gain weight
If you maintain or even increase your muscle mass this season, you are already closer to your goal than you think. It is true that diet is overall more important than physical activity in long term. During the holiday season though, exercise can significantly help you to maintain your current weight!
The Winter Weight Watch Study is the most recent randomized controlled trial on controlling holiday gain. The results showed that information on the types and duration of exercise you need to “burn” the energy of festive foods and drinks has contributed to prevent weight gain during the holidays !
Even if you are spending holidays abroad or you are busy with your guests, you do not need to go to the gym or workout for long. You can find 20-30 minute workout videos online free. You may choose equipment-free workouts or you can take a resistance band with you. The goal is to exercise as frequently as usual!
5. Include walking to your holiday activities.
Walking for gift and souvenir shopping, sightseeing, or to enjoy time with friends is a great way to avoid weight gain during the holidays. And it’s not just about weight gain. Even 20 minutes of walking per day can significantly reduce the heart disease risk ! Daily walking is an amazing healthy habit to maintain throughout the year and not just to avoid weight gain.
You can easily spend the calories of an appetizer or a drink without even noticing by walking 1-2 hours per day in total. Spending time outside is also a great way to distract yourself from snacking. Check this blog post from Harvard’s Medical School for more calorie burning daily activities!
Do you have any fitness tips for the holiday season? Leave a comment and let everyone know!
References
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1.
Sams A, Hawks J. Celiac disease as a model for the evolution of multifactorial disease in humans. Hum Biol. 2014;86(1):19–36.
1.
Garcia-Mazcorro JF, Noratto G, Remes-Troche JM. The Effect of Gluten-Free Diet on Health and the Gut Microbiota Cannot Be Extrapolated from One Population to Others. Nutrients [Internet]. 2018 Oct 4 [cited 2020 Jul 10];10(10). Available from:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212913/
1.
De Palma G, Nadal I, Collado MC, Sanz Y. Effects of a gluten-free diet on gut microbiota and immune function in healthy adult human subjects. Br J Nutr. 2009 Oct;102(8):1154–60.
1.
Kim H, Demyen MF, Mathew J, Kothari N, Feurdean M, Ahlawat SK. Obesity, Metabolic Syndrome, and Cardiovascular Risk in Gluten-Free Followers Without Celiac Disease in the United States: Results from the National Health and Nutrition Examination Survey 2009–2014. Dig Dis Sci [Internet]. 2017 Sep 1 [cited 2020 Jul 10];62(9):2440–8. Available from:
https://doi.org/10.1007/s10620-017-4583-1
1.
Catassi C, Alaedini A, Bojarski C, Bonaz B, Bouma G, Carroccio A, et al. The Overlapping Area of Non-Celiac Gluten Sensitivity (NCGS) and Wheat-Sensitive Irritable Bowel Syndrome (IBS): An Update. Nutrients [Internet]. 2017 Nov [cited 2020 Jul 10];9(11):1268. Available from:
https://www.mdpi.com/2072-6643/9/11/1268
1.
Lebwohl B, Cao Y, Zong G, Hu FB, Green PHR, Neugut AI, et al. Long term gluten consumption in adults without celiac disease and risk of coronary heart disease: prospective cohort study. BMJ [Internet]. 2017 May 2 [cited 2020 Jul 10];357. Available from:
https://www.bmj.com/content/357/bmj.j1892
1.
Caio G, Volta U, Sapone A, Leffler DA, De Giorgio R, Catassi C, et al. Celiac disease: a comprehensive current review. BMC Medicine [Internet]. 2019 Jul 23 [cited 2020 Jul 9];17(1):142. Available from:
https://doi.org/10.1186/s12916-019-1380-z
1.
Ehteshami M, Shakerhosseini R, Sedaghat F, Hedayati M, Eini-Zinab H, Hekmatdoost A. The Effect of Gluten Free Diet on Components of Metabolic Syndrome: A Randomized Clinical Trial. Asian Pac J Cancer Prev [Internet]. 2018 [cited 2020 Jul 9];19(10):2979–84. Available from:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291063/
1.
Menon V, Kar SK, Suthar N, Nebhinani N. Vitamin D and Depression: A Critical Appraisal of the Evidence and Future Directions. Indian J Psychol Med [Internet]. 2020 Jan 6 [cited 2020 Jul 7];42(1):11–21. Available from:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6970300/
1.
Vanherwegen A-S, Gysemans C, Mathieu C. Vitamin D endocrinology on the cross-road between immunity and metabolism. Mol Cell Endocrinol. 2017 15;453:52–67.
1.
Umar M, Sastry KS, Chouchane AI. Role of Vitamin D Beyond the Skeletal Function: A Review of the Molecular and Clinical Studies. International Journal of Molecular Sciences [Internet]. 2018 Jun [cited 2020 Jul 7];19(6):1618. Available from:
https://www.mdpi.com/1422-0067/19/6/1618
1.
Armah SM, Boy E, Chen D, Candal P, Reddy MB. Regular Consumption of a High-Phytate Diet Reduces the Inhibitory Effect of Phytate on Nonheme-Iron Absorption in Women with Suboptimal Iron Stores. J Nutr. 2015 Aug;145(8):1735–9.
1.
Al Hasan SM, Hassan M, Saha S, Islam M, Billah M, Islam S. Dietary phytate intake inhibits the bioavailability of iron and calcium in the diets of pregnant women in rural Bangladesh: a cross-sectional study. BMC Nutrition [Internet]. 2016 Apr 21 [cited 2020 Jul 1];2(1):24. Available from:
https://doi.org/10.1186/s40795-016-0064-8
1.
Beck KL, Conlon CA, Kruger R, Coad J. Dietary Determinants of and Possible Solutions to Iron Deficiency for Young Women Living in Industrialized Countries: A Review. Nutrients [Internet]. 2014 Sep 19 [cited 2020 Jul 1];6(9):3747–76. Available from:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4179187/
1.
Lönnerdal B. Calcium and iron absorption--mechanisms and public health relevance. Int J Vitam Nutr Res. 2010 Oct;80(4–5):293–9.
1.
Chambers ES, Preston T, Frost G, Morrison DJ. Role of Gut Microbiota-Generated Short-Chain Fatty Acids in Metabolic and Cardiovascular Health. Curr Nutr Rep [Internet]. 2018 [cited 2020 Jun 28];7(4):198–206. Available from:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244749/
1.
Saltiel AR, Kahn CR. Insulin signalling and the regulation of glucose and lipid metabolism. Nature [Internet]. 2001 Dec [cited 2020 Jun 27];414(6865):799–806. Available from:
https://www.nature.com/articles/414799a
1.
Poulsen SK, Due A, Jordy AB, Kiens B, Stark KD, Stender S, et al. Health effect of the New Nordic Diet in adults with increased waist circumference: a 6-mo randomized controlled trial. Am J Clin Nutr [Internet]. 2014 Jan 1 [cited 2020 Jun 27];99(1):35–45. Available from:
https://academic.oup.com/ajcn/article/99/1/35/4577343
1.
Ledikwe JH, Rolls BJ, Smiciklas-Wright H, Mitchell DC, Ard JD, Champagne C, et al. Reductions in dietary energy density are associated with weight loss in overweight and obese participants in the PREMIER trial. Am J Clin Nutr [Internet]. 2007 May 1 [cited 2020 Jun 27];85(5):1212–21. Available from:
https://academic.oup.com/ajcn/article/85/5/1212/4754403
1.
Jovanovski E, Mazhar N, Komishon A, Khayyat R, Li D, Blanco Mejia S, et al. Can dietary viscous fiber affect body weight independently of an energy-restrictive diet? A systematic review and meta-analysis of randomized controlled trials. Am J Clin Nutr [Internet]. 2020 Feb 1 [cited 2020 Jun 27];111(2):471–85. Available from:
https://academic.oup.com/ajcn/article/111/2/471/5695296
1.
Miketinas DC, Bray GA, Beyl RA, Ryan DH, Sacks FM, Champagne CM. Fiber Intake Predicts Weight Loss and Dietary Adherence in Adults Consuming Calorie-Restricted Diets: The POUNDS Lost (Preventing Overweight Using Novel Dietary Strategies) Study. J Nutr [Internet]. 2019 Oct 1 [cited 2020 Jun 27];149(10):1742–8. Available from:
https://academic.oup.com/jn/article/149/10/1742/5512578
Summary
Article Name
5 easy tips to avoid weight gain during holidays
Description
Realistic advice to avoid excessive weight gain during holidays this year. A few every day tips can help you maintain your weight.
Author
Maria Tikka