The cover's background is pastel blue with marble effect. Text on the bottom: All you need to know about Vitamin D! @Nutrition by Maria Tikka. Two sets of pastel pink and light blue flowers are on the right and left of the title. Two framed sunset photos are on the center.
July 7, 2020

All about Vitamin D functions and food sources!

By Maria Tikka ANutr, MMedSci
ibiza sunset cover for vitamin D article

Today’s topic is learning a few facts about Vitamin D & reliable food sources!

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You can find information for UK supplementation guidelines in the NHS website and SACN vitamin D report . Especially now due to the “stay-in situation”, it is important to check any updates on your country’s supplementation guidelines!

It has recently been suggested that maintaining a normal Vitamin D status is important to protect our health during these difficult times and that vitamin D deficiency risk is increased due to staying inside . Let’s keeping in mind some important information about this nutrient.

A few facts about vitamin D

  • It can be produced after skin exposure to sunlight when the time of the day, latitude and wavelength (290-315nm) are appropriate. In the UK and most north hemisphere countries, these factors are met between March and September. In this aspect, since it is produced by skin cells, Vitamin D acts as a pre-hormone .
  • Vitamin D is a fat soluble vitamin. It meets the criteria to be a vitamin, since it is an organic substance found in small amounts in food, it is nessecary to maintain our health and its deficiency can cause diseases.
  • It can be recieved from food in the form of Vitamin D3 and Vitamin D2.
  • During winter, or in presense of other factors that prevent adequate exposure to sunlight, dietary intake of Vitamin D is nessecary to achieve adequate intake , .
  • In the UK, the recommended dietary intake for adults and children older than 1 years old is 10μg (400 IU)/day .
  • Vitamin D intake greater than 4000 IU/day (100 μg) could be harmful .
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Vitamin D functions

  • Maintain normal calcium blood levels: When calcium blood levels are low, Vitamin D induces calcium absorption in the small intestine, calcium reabsorption in the kidneys and calcium release from bones. The goal is to increase calcium concentration in the blood .
  • Has a role in regulating phosphorus absorption .
  • Role in immune system regulation: The active form of vitamin D (1,25 (OH)2 D3) enhances the production of substances with anti- microbial properties by macrophages and monocytes keratinocytes. Also, 1,25 (OH)2 D3 production by immune cells is increased in presence of inflammatory signals .
  • Possible role in depression treatment: Brain areas that have a role in the pathophysiology of depression have Vitamin D receptors. Also, it is possible that by regulating calcium homeostasis, the signaling of the neurotransmitters GABA and glumate is positively affected. However, evidence is still inadequate .
  • Vitamin D active metabolites participate in the expression of genes important for cell apoptosis, differentiation and prolifration . Due to this role in cell apoptosis, it is possible that a healthy vitamin D status could decrease the risk for some forms of cancer .

Rich Vitamin D food sources :

Foodμg Vitamin D (D2 + D3)/100g
Trout, steamed20
Salmon, smoked17.1
Mackerel, raw13.8
Salmon, raw10.9
Sardines, dry10.1
Seabass, steamed7
Pork spareribs, cooked2.5
Egg, whole, raw2
Veal patty,cooked1.8
Pork sausages1.4
Milk, whole1.3
Oatmeal maked with milk1.2
Beef liver, braised or fried1.2
Milk, reduced fat (2%)1.2
Low fat plain yogurt1.2
Soy milk1.1
Kefir1
Almond milk, unsweetened1
Coconut milk yogurt0.9
Mushrooms, raw0.2
meal with vitamin d sources including salmon and mushrooms
Steamed salmon with mushrooms and other steamed veggies. A great example of a meal rich in vitamins C & D and fibre.

In the UK, margarine fortification with Vitamin D is mandatory. Other foods that could be fortified include :

  • Infant and follow-on formula milks which are fortified
  • and some cereal and yogurt brands
  • Fortified milks

To sum up, good dietary vitamin D sources are quite rare and consuming the amount we need exclusively from food could be hard. Sunlight is normally the main vitamin D source during spring and summer.

This year though, our safety is the priority. Please check your area’s guidelines regarding social distancing or isolation. If it is unsafe for you to go outside, paying more attention to your nutrition and consulting with a healthcare professional about the possibility of supplementation is definitely worth it!

References

1.
Jones AL. The Gluten-Free Diet: Fad or Necessity? Diabetes Spectr [Internet]. 2017 May [cited 2020 Jul 10];30(2):118–23. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5439366/
1.
What is Celiac Disease? [Internet]. Celiac Disease Foundation. [cited 2020 Jul 10]. Available from: https://celiac.org/about-celiac-disease/what-is-celiac-disease/
1.
Kupfer SS, Jabri B. Celiac Disease Pathophysiology. Gastrointest Endosc Clin N Am [Internet]. 2012 Oct [cited 2020 Jul 10];22(4). Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3872820/
1.
Kagnoff MF. Celiac disease: pathogenesis of a model immunogenetic disease. J Clin Invest [Internet]. 2007 Jan 2 [cited 2020 Jul 10];117(1):41–9. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1716218/
1.
Sams A, Hawks J. Celiac disease as a model for the evolution of multifactorial disease in humans. Hum Biol. 2014;86(1):19–36.
1.
Free-from moves mainstream [Internet]. Agriculture and Horticulture Development Board (AHDB). 2018. Available from: https://ahdb.org.uk/news/consumer-insight-free-from-moves-mainstream-2
1.
Gluten-Free Products Market Size, Share | Industry Report, 2027 [Internet]. [cited 2020 Jul 10]. Available from: https://www.grandviewresearch.com/industry-analysis/gluten-free-products-market
1.
Garcia-Mazcorro JF, Noratto G, Remes-Troche JM. The Effect of Gluten-Free Diet on Health and the Gut Microbiota Cannot Be Extrapolated from One Population to Others. Nutrients [Internet]. 2018 Oct 4 [cited 2020 Jul 10];10(10). Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212913/
1.
De Palma G, Nadal I, Collado MC, Sanz Y. Effects of a gluten-free diet on gut microbiota and immune function in healthy adult human subjects. Br J Nutr. 2009 Oct;102(8):1154–60.
1.
Kim H, Demyen MF, Mathew J, Kothari N, Feurdean M, Ahlawat SK. Obesity, Metabolic Syndrome, and Cardiovascular Risk in Gluten-Free Followers Without Celiac Disease in the United States: Results from the National Health and Nutrition Examination Survey 2009–2014. Dig Dis Sci [Internet]. 2017 Sep 1 [cited 2020 Jul 10];62(9):2440–8. Available from: https://doi.org/10.1007/s10620-017-4583-1
1.
What is Gluten? [Internet]. Celiac Disease Foundation. [cited 2020 Jul 10]. Available from: https://celiac.org/gluten-free-living/what-is-gluten/
1.
Catassi C, Alaedini A, Bojarski C, Bonaz B, Bouma G, Carroccio A, et al. The Overlapping Area of Non-Celiac Gluten Sensitivity (NCGS) and Wheat-Sensitive Irritable Bowel Syndrome (IBS): An Update. Nutrients [Internet]. 2017 Nov [cited 2020 Jul 10];9(11):1268. Available from: https://www.mdpi.com/2072-6643/9/11/1268
1.
Lebwohl B, Cao Y, Zong G, Hu FB, Green PHR, Neugut AI, et al. Long term gluten consumption in adults without celiac disease and risk of coronary heart disease: prospective cohort study. BMJ [Internet]. 2017 May 2 [cited 2020 Jul 10];357. Available from: https://www.bmj.com/content/357/bmj.j1892
1.
Overview | Coeliac disease: recognition, assessment and management | Guidance | NICE [Internet]. [cited 2020 Jul 9]. Available from: https://www.nice.org.uk/guidance/ng20/
1.
Caio G, Volta U, Sapone A, Leffler DA, De Giorgio R, Catassi C, et al. Celiac disease: a comprehensive current review. BMC Medicine [Internet]. 2019 Jul 23 [cited 2020 Jul 9];17(1):142. Available from: https://doi.org/10.1186/s12916-019-1380-z
1.
Ehteshami M, Shakerhosseini R, Sedaghat F, Hedayati M, Eini-Zinab H, Hekmatdoost A. The Effect of Gluten Free Diet on Components of Metabolic Syndrome: A Randomized Clinical Trial. Asian Pac J Cancer Prev [Internet]. 2018 [cited 2020 Jul 9];19(10):2979–84. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291063/
1.
Niland B, Cash BD. Health Benefits and Adverse Effects of a Gluten-Free Diet in Non–Celiac Disease Patients. Gastroenterol Hepatol (N Y) [Internet]. 2018 Feb [cited 2020 Jul 9];14(2):82–91. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866307/
1.
Diez-Sampedro A, Olenick M, Maltseva T, Flowers M. A Gluten-Free Diet, Not an Appropriate Choice without a Medical Diagnosis. J Nutr Metab [Internet]. 2019 Jul 1 [cited 2020 Jul 9];2019. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6636598/
1.
Prevention of vitamin D deficiency [Internet]. BJFM. [cited 2020 Jul 7]. Available from: https://www.bjfm.co.uk/prevention-of-vitamin-d-deficiency
1.
Gropper SS, Smith JL, Groff JL. Advanced nutrition and human metabolism [Internet]. 5th ed. Wadsworth Cengage Learning; 2009. 600 p. Available from: https://books.google.co.uk/books?id=rXSO9YLr72YC&printsec=frontcover&hl=el&source=gbs_ge_summary_r&cad=0#v=onepage&q&f=false
1.
Young MRI, Xiong Y. Influence of vitamin D on cancer risk and treatment: Why the variability? Trends Cancer Res [Internet]. 2018 [cited 2020 Jul 7];13:43–53. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201256/
1.
Menon V, Kar SK, Suthar N, Nebhinani N. Vitamin D and Depression: A Critical Appraisal of the Evidence and Future Directions. Indian J Psychol Med [Internet]. 2020 Jan 6 [cited 2020 Jul 7];42(1):11–21. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6970300/
1.
Vanherwegen A-S, Gysemans C, Mathieu C. Vitamin D endocrinology on the cross-road between immunity and metabolism. Mol Cell Endocrinol. 2017 15;453:52–67.
1.
Umar M, Sastry KS, Chouchane AI. Role of Vitamin D Beyond the Skeletal Function: A Review of the Molecular and Clinical Studies. International Journal of Molecular Sciences [Internet]. 2018 Jun [cited 2020 Jul 7];19(6):1618. Available from: https://www.mdpi.com/1422-0067/19/6/1618
1.
SACN vitamin D and health report [Internet]. GOV.UK. [cited 2020 Jul 7]. Available from: https://www.gov.uk/government/publications/sacn-vitamin-d-and-health-report
1.
Vitamins and minerals - Vitamin D [Internet]. nhs.uk. 2017 [cited 2020 Jul 7]. Available from: https://www.nhs.uk/conditions/vitamins-and-minerals/vitamin-d/
1.
Lanham-New SA, Webb AR, Cashman KD, Buttriss JL, Fallowfield JL, Masud T, et al. Vitamin D and SARS-CoV-2 virus/COVID-19 disease. BMJ Nutrition, Prevention & Health [Internet]. 2020 May 13 [cited 2020 Jul 6];bmjnph. Available from: https://nutrition.bmj.com/content/early/2020/06/09/bmjnph-2020-000089
1.
Sassi F, Tamone C, D’Amelio P. Vitamin D: Nutrient, Hormone, and Immunomodulator. Nutrients [Internet]. 2018 Nov 3 [cited 2020 Jul 6];10(11). Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266123/
1.
Armah SM, Boy E, Chen D, Candal P, Reddy MB. Regular Consumption of a High-Phytate Diet Reduces the Inhibitory Effect of Phytate on Nonheme-Iron Absorption in Women with Suboptimal Iron Stores. J Nutr. 2015 Aug;145(8):1735–9.
1.
Al Hasan SM, Hassan M, Saha S, Islam M, Billah M, Islam S. Dietary phytate intake inhibits the bioavailability of iron and calcium in the diets of pregnant women in rural Bangladesh: a cross-sectional study. BMC Nutrition [Internet]. 2016 Apr 21 [cited 2020 Jul 1];2(1):24. Available from: https://doi.org/10.1186/s40795-016-0064-8
1.
Beck KL, Conlon CA, Kruger R, Coad J. Dietary Determinants of and Possible Solutions to Iron Deficiency for Young Women Living in Industrialized Countries: A Review. Nutrients [Internet]. 2014 Sep 19 [cited 2020 Jul 1];6(9):3747–76. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4179187/
1.
Lönnerdal B. Calcium and iron absorption--mechanisms and public health relevance. Int J Vitam Nutr Res. 2010 Oct;80(4–5):293–9.
1.
Miller JL. Iron Deficiency Anemia: A Common and Curable Disease. Cold Spring Harb Perspect Med [Internet]. 2013 Jul [cited 2020 Jul 1];3(7). Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3685880/
1.
Geissler C, Powers H. Human Nutrition [Internet]. 12th ed. Churchill Livingstone; 2010. 792 p. Available from: https://www.elsevier.com/books/human-nutrition/geissler/978-0-7020-3118-2
1.
1.
In.
1.
Geissler C, Powers H. Human Nutrition - 12th Edition [Internet]. [cited 2020 Jul 1]. Available from: https://www.elsevier.com/books/human-nutrition/geissler/978-0-7020-3118-2
1.
Mann J, Truswell AS. Essentials of HumanNutrition [Internet]. Second. OXFORD UNIVERSITY PRESS; 2002. Available from: http://ssu.ac.ir/cms/fileadmin/user_upload/Mtahghighat/taghzie_imani/book/Essentials%20of%20Human%20Nutrition.pdf
1.
SACN Iron and Health Report [Internet]. GOV.UK. [cited 2020 Jul 1]. Available from: https://www.gov.uk/government/publications/sacn-iron-and-health-report
1.
WHO | Micronutrient deficiencies [Internet]. WHO. [cited 2020 Jul 1]. Available from: http://www.who.int/nutrition/topics/ida/en/
1.
Chambers ES, Preston T, Frost G, Morrison DJ. Role of Gut Microbiota-Generated Short-Chain Fatty Acids in Metabolic and Cardiovascular Health. Curr Nutr Rep [Internet]. 2018 [cited 2020 Jun 28];7(4):198–206. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244749/
1.
Slavin J, Green H. Dietary fibre and satiety. Nutrition Bulletin [Internet]. 2007 [cited 2020 Jun 28];32(s1):32–42. Available from: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1467-3010.2007.00603.x
1.
Saltiel AR, Kahn CR. Insulin signalling and the regulation of glucose and lipid metabolism. Nature [Internet]. 2001 Dec [cited 2020 Jun 27];414(6865):799–806. Available from: https://www.nature.com/articles/414799a
1.
Poulsen SK, Due A, Jordy AB, Kiens B, Stark KD, Stender S, et al. Health effect of the New Nordic Diet in adults with increased waist circumference: a 6-mo randomized controlled trial. Am J Clin Nutr [Internet]. 2014 Jan 1 [cited 2020 Jun 27];99(1):35–45. Available from: https://academic.oup.com/ajcn/article/99/1/35/4577343
1.
Ledikwe JH, Rolls BJ, Smiciklas-Wright H, Mitchell DC, Ard JD, Champagne C, et al. Reductions in dietary energy density are associated with weight loss in overweight and obese participants in the PREMIER trial. Am J Clin Nutr [Internet]. 2007 May 1 [cited 2020 Jun 27];85(5):1212–21. Available from: https://academic.oup.com/ajcn/article/85/5/1212/4754403
1.
Pauline K-B, Rimm EB. Whole grain consumption and weight gain: a review of the epidemiological evidence, potential mechanisms and opportunities for future research. Proceedings of the Nutrition Society [Internet]. 2003 Feb [cited 2020 Jun 27];62(1):25–9. Available from: https://www.cambridge.org/core/journals/proceedings-of-the-nutrition-society/article/whole-grain-consumption-and-weight-gain-a-review-of-the-epidemiological-evidence-potential-mechanisms-and-opportunities-for-future-research/8611B1F76241BB44A24B6F8A3314925D
1.
Jovanovski E, Mazhar N, Komishon A, Khayyat R, Li D, Blanco Mejia S, et al. Can dietary viscous fiber affect body weight independently of an energy-restrictive diet? A systematic review and meta-analysis of randomized controlled trials. Am J Clin Nutr [Internet]. 2020 Feb 1 [cited 2020 Jun 27];111(2):471–85. Available from: https://academic.oup.com/ajcn/article/111/2/471/5695296
1.
Miketinas DC, Bray GA, Beyl RA, Ryan DH, Sacks FM, Champagne CM. Fiber Intake Predicts Weight Loss and Dietary Adherence in Adults Consuming Calorie-Restricted Diets: The POUNDS Lost (Preventing Overweight Using Novel Dietary Strategies) Study. J Nutr [Internet]. 2019 Oct 1 [cited 2020 Jun 27];149(10):1742–8. Available from: https://academic.oup.com/jn/article/149/10/1742/5512578

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All about Vitamin D functions and food sources!
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All about Vitamin D functions and food sources!
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Facts about Vitamin D, reliable food sources and UK recommendations!
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